This page highlights peer-reviewed publications from our investigators and collaborators advancing the understanding and treatment of hydrocephalus.
Publications
Hochstetler A, Newland V, Davis C, Blazer-Yost BL. Relationship between TRPV4, NKCC1 and lysophosphatidic acid in fluid and electrolyte secretion in a pre-clinical model of the human choroid plexus epithelium. Am. J. Physiol: Cell Physiol. In Revision
Audu D, Reed M, Blazer-Yost BL. TRPV4 antagonism attenuates TLR4-NLRP3-mediated neuroinflammation and oxidative stress in cingulate cortex neurons in a genetic rat model of hydrocephalus. J. Neuroinflam. In revision
Blazer-Yost BL, McComb JG. Hugh Davson: The scientist and his science. Am. J. Physiol: Cell Physiol 329:C675-C681, 2025.
https://doi.org/10.1152/ajpcell.00399.2025
Newland V, Jantzie LL, Blazer-Yost BL. Understanding and modeling the pathophysiology of hydrocephalus: In search of better treatment options. Physiologia 4:182-201, 2024
https://doi.org/10.3390/physiologia4020010
Hochstetler AE, Smith HM, Hulme LS, Reed MM, Perrotti N, D’Antona L, Schenone S, Musumeci F, Territo P, Persohn S, Blazer-Yost BL. Inhibition of Serum- and Glucocorticoid- Induced Kinase 1 ameliorates hydrocephalus in preclinical models. Fluid Barriers CNS 20:61, 2023
https://doi.org/10.1186/s12987-023-00461-0
Blazer-Yost, B.L. Consideration of Kinase Inhibitors for the Treatment of Hydrocpehalus. Kinase Inhibitors in Genetic Diseases Int. J. Mol. Sci. 24:6673, 2023
https://doi.org/10.3390/ijms24076673
D’Antona L, Amato R, Brescia C, Rocca V, Colao E, Iuliano R, Blazer-Yost BL, Perrotti N. Kinase Inhibitors in Genetic Diseases. Int. J. Mol. Sci. 24, 5276, 2023
https://doi.org/10.3390/ijms24065276
Hulme, L., Hochstetler, A., C. Schwerk, H. Schroten, H. Ishikawa, C-Y. Tung, B. Perrin, B. L. Blazer-Yost. Characterization of TRPV4-mediated signaling pathways in an optimized choroid plexus epithelial cell line. Am. J. Physiol: Cell Physiol 323:C1823-C1842, 2022
https://doi.org/10.1152/ajpcell.00193.2022
Hochstetler, A.E, J. Raskin, Blazer-Yost, B.L. Hydrocephalus: Historical Analysis and Considerations for Treatment. Eur. J. Med. Res. 22:168, 2022
https://doi.org/10.1186/s40001-022-00798-6
Blazer-Yost, B.L. Following Ussing’s Legacy: From amphibian models to mammalian kidney and brain. Note: manuscript accompanying the Hans Ussing Award Lecture of the American Physiological Society. Am. J. Physiol: Cell Physiol 323: C1061-C1069, 2022
https://doi.org/10.1152/ajpcell.00303.2022
Hochstetler, A.E, L. Hulme, E. Delpire, C. Schwerk, H. Schroten, D. Preston. S. Simpson, B.L. Blazer-Yost. Porcine Choroid Plexus – Riems cell line demonstrates altered polarization of transport protein in comparison with the native epithelium. Am. J. Physiol: Cell Physiol. 323: C1-C13, 2022.
https://journals.physiology.org/doi/prev/20220504-aop/epdf/10.1152/ajpcell.00374.2021
Reed, M., B. L. Blazer-Yost, Channels and Transporters in Astrocyte Volume Regulation in Health and Disease. Cell. Physiol. Biochem. 56: 12-30, 2022
https://doi.org/10.33594/000000495
Blazer-Yost, B.L., R.L. Bacallao, B.J. Erickson, M.L. LaPradd, M.E. Edwards, N. Sheth, K. Swinney, K.M. Ponsler-Sipes, R.N. Moorthi, S.M. Perkins, V.E. Torres, S.M. Moe. A Phase 1b Study of Safety of Low Dose Pioglitazone for Treatment of ADPKD. Clin. Kidn. J. 14:1738–1746, 2021
https://doi.org/10.1093/ckj/sfaa232
Hochstetler, A.E. H.M. Smith, D.C. Preston, M.M. Reed, P.R Territo, J.W. Shim, D. Fulkerson, B.L. Blazer-Yost. TRPV4 Antagonists Ameliorate Ventriculomegaly in a Rat Model of Hydrocephalus. J. Clin. Invest.: Insight 5(18): e137646, 2020
https://doi.org/10.1172/jci.insight.137646
Simpson, S., D. Preston, C. Schwerk, H. Schroten, B.L. Blazer-Yost. Cytokine and inflammatory mediator effects on TRPV4 function in choroid plexus epithelial cells. Am. J. Physiol. Cell Physiol. 317: C881-C893, 2019
https://doi.org/10.1152/ajpcell.00205.2019
Shim, J.W., P.R. Territo, S. Simpson, J.C. Watson, L. Jiang, A.A. Riley, B. McCarthy, S. Persohn, D. Fulkerson, B.L. Blazer-Yost. Hydrocephalus in a rat model of Meckel Gruber Syndrome with a TMEM67 mutation Sci. Report 9:1069, 2019
https://www.nature.com/articles/s41598-018-37620-5
Preston, D., S. Simpson, D. Halm, A. Hochstetler, C. Schwerk, H. Schroten, B.L. Blazer-Yost, Activation of TRPV4 in a porcine choroid plexus cell line. Am. J. Physiol. Cell Physiol. 315: C357-C366, 2018.