Chemistry is at the heart of a wide variety of scientific efforts. By working with partners from many different areas in cross-disciplinary research centers, we can expand the scope of our projects and have an even bigger impact on the world.
Along with knowledge and expertise, we share facilities and equipment.
Research centers we partner with
This center at the IU School of Medicine performs world class, cutting edge research in computational biology and bioinformatics. It places special emphasis on the problems of identifying the functions and structures of various protein entities in a manner that stimulates both academic and commercial collaborations.
Membrane-related research is at the forefront of challenges in modern biology, presenting some of the greatest problems in structural determination and functional characterization
Using the techniques of nuclear magnetic resonance, the Nuclear Magnetic Resonance Center conducts basic and applied research on metabolism, and on structure-function relationships of biological macromolecules.
The Center for Structural Biology is a multidisciplinary facility for experimental investigations designed to examine the structural and functional characteristics of biological macromolecules and how these changes in these properties relate to specific diseases.
Projects currently under investigation are examining the underlying mechanisms for alcoholism, cancer, diabetes, liver, and heart disease.
We have joined forces with the IU Simon Cancer Center to create a core facility for chemical synthesis and organic drug lead development to expedite the translational research and drug development efforts of cancer researchers.
The goal of the center is to support the synthetic and medicinal chemistry needs of IUSCC investigators as well as other academic entities within IU Indianapolis and throughout the state. The core is also available to the broader life sciences industrial community of central Indiana and elsewhere on a contract basis.
The mission of the Indiana Institute for Biomedical Imaging Sciences is to promote human health through the application of advanced biomedical imaging technologies. The institute serves the academic, medical, and business communities of Indiana.
The center serves as a focal point for multi-institutional collaboration in basic and applied research to develop novel biomedical imaging technologies and is home to a state-of-the-art biomedical imaging facilty.
The Indiana University Melvin and Bren Simon Comprehensive Cancer Center is a patient care, research, and educational organization within the IU School of Medicine.
Its mission is to advance the understanding, prevention, and treatment of cancer throughout Indiana and the world with patient-centered care, acceleration of promising science, and collaborative educational programs.
INDI is dedicated to advancing nanotechnology-focused research, education, and outreach across campus and throughout the surrounding region. With a growing body nanoscale characterization, fabrication, and analytical instrumentation, coupled with technical expertise and proposal development services, INDI not only boosts research collaboration but also provides enhanced student development via training and integration into coursework. The impact of these efforts span INDI’s diverse 30+ faculty members (from four different IU Indianapolis schools) to surrounding Universities, local industry, and the neighboring K-12 community. Together, INDI is not only meeting the needs of current nanotechnology researchers, but is also working to foster the next generation of the STEM workforce.
Our department has state-of-the-art equipment available for our researchers and their student teams.
Bruker Avance III 500 MHz NMR (with solid-state analysis and magic angle spinning capabilities, a 1.7 mm inverse probe, 5mm triple resonance inverse probe, 5mm broadband probe, and a 60 sample sample-changer allowing remote data acquisition and processing).
Varian Gemini 2000 200 MHz FT-NMR
Varian Gemini 2000 200 MHz FT-NMR
Agilent 6890-5973 GC-MS System
Agilent 7890-5975C GC-MS System with an FID detector
Agilent 1100-6130 LC-MS (2 instruments)
Agilent 1200-6410 LC-MS (rapid resolution HPLC with a triple quadrupole mass spectrometer)
Agilent 1200-6520 LC-MS (Capillary HPLC with a quadrupole-time-of-flight mass spectrometer
Siemens/Bruker AXS D5000 Automated Powder X-ray Diffractometer (via the Department of Geology)
Schoeffer LH 151-N/1S High Intensity Photolysis Apparatus
Johnson Matthey MK2 Magnetic Susceptibility Balance
NIMA PS4 Surface Pressure Balance
Innovative Technologies Lab Master 100 Glovebox
CHI 760D Electrochemical workstation
Facilities
Below are several faciltities dedicated to specific pursuits.
The Biochemistry Biotechnology Facility (BBF) offers an automated DNA sequencing service which can be used for sequence of analysis of plasmid, PCR, and large DNA samples. This service utilizes a Perkin Elmer/Applied Biosystems 3100 Genetic Analyzer and Big Dye Terminator chemistry v3.1.
The Laboratory for Computational Molecular Science maintains 2 Silicon Graphics High Resolution Graphics Workstations and offers an array of molecular modeling and quantum mechanical software.
Software available
MSI QUANTA/CHARM
Cerius
Tripos Sybil
Spartan
MacroModel
Mathematica
Hardware available
Two Dell work stations
Two Mac work stations
Two SG work stations
The Department also maintains numerous microcomputer workstations, superminicomputers, and monochrome/color high-resolution printers.
There are about 1,000 additional micros/UNIX workstations available to students at public clusters throughout the university.
Virtually all campus computers are connected by a major fiber optic ethernet backbone with ready access to the World Wide Web. We are also a core site for the Abilene Internet 2 Project.
The Department of Chemistry and Chemical Biology operates a mass spectrometry (MS) facility to provide top-quality MS support for students and researchers.
We currently specialize in walk-up MS analysis for GC-MS and LC-MS to provide hands-on MS instrumentation training.
Instruments currently available for walk-up use include:
An Agilent 6890-5973 GC-MS
An Agilent 7890-5975 GC-FID/GC-MS
An Agilent 1100-6130A LC-MS with ESI
This facility also contains an Agilent 1200SL-6410 rapid resolution LC-Triple Quad MS with sensitivity upgrade and an Agilent 1200-6520 capillary LC-Q-TOF MS.
These two instruments were obtained through a National Science Foundation grant to support multiple research efforts. While they are not currently available for walk-up use, arrangements can be made for sample analysis by staff, or researcher training for larger projects if instrument time is available.
The facility also contains a SpectrumMill MS proteomics workbench, Bioconfirm, Mass Profiler, Mass profiler Professional, and a METLIN database for data analysis.
The Nanoscale Imaging Center (NIC) completes the existing biomedical imaging capabilities on campus, along with the Indiana Center of Excellence in BioMedical Imaging (IN-CEBI) with its whole body imaging focus, and the Indiana Center for Biological Microscopy with its cellular level imaging focus.
The NIC anchors a campus effort to investigate the behavior of single molecules and nanostructures, with an emphasis on medical, biological, and materials science applications.
NIC focus includes the broad areas of:
Subcellular imaging Biomimetics for biomaterials and biosensors
Nanotechnology and development of next generation nanoscale imaging probes and instrumentation