• Skip to Content
  • Skip to Main Navigation
  • Skip to Search

School of ScienceIndianapolis
  • Biology
  • Chemistry & Chemical Biology
  • Computer Science
  • Earth and Environmental Sciences
  • Forensic & Investigative Sciences
  • Mathematical Sciences
  • Neuroscience
  • Physics
  • Psychology
  • School of Science main site
  • Biology
  • Chemistry & Chemical Biology
  • Computer Science
  • Earth and Environmental Sciences
  • Forensic & Investigative Sciences
  • Mathematical Sciences
  • Neuroscience
  • Physics
  • Psychology
  • School of Science main site
School of Science
  • About
    • Dean's Welcome
    • Dean's Advisory Council
    • Facts & Statistics
    • Science Stories
    • News
    • Events
    • IU Indianapolis
    • Community Outreach
    • Employment Opportunities
    • Contact
  • Admissions
    • Apply
    • Visit
    • Financial Aid & Scholarships
    • Admitted Students
  • Academics
    • Areas of Study
    • Degrees & Programs
    • Honors Program
    • Course Descriptions
    • Study Abroad
    • Academic Support
    • Dean's List and Science Scholars
    • Graduation
    • Commencement
    • Poster Printing
  • Research
    • Centers & Partners
    • Student Opportunities
  • Student Life
    • Live & Learn Downtown
    • Student Organizations
    • Housing
  • Career Services
    • Advising
    • Career Tools
    • Handshake
    • Graduate & Professional School Planning
    • For Employers
    • Faculty & Staff
    • Internship Scholarship
    • Elective Courses
    • Career Fairs
    • Health Professions Fair
    • Events
    • Contact Us
  • Alumni & Giving
    • Give to Science
    • Get Involved
    • Events
    • Stories
    • Contact Us
  • People Directory
  • Home
  • About
  • News
  • Physics Researchers use Big Red II to Assess Vitamin E’s Ability to Protect Vital Fatty Acids(3836)

Physics Researchers use Big Red II to Assess Vitamin E’s Ability to Protect Vital Fatty Acids

Monday, June 18, 2018


Omega-3 polyunsaturated acids (n-3 PUFA) are fatty acids found in fish oils that have multiple health benefits. Various research has shown that dietary consumptions of fish oils can help with cardiovascular diseases, cancer preventions, inflammatory processes, and metabolism improvements. However, it is easy for these fatty acids to be oxidized, and once oxidation happens, health benefits are likely to be lost. Therefore, it is crucial for science to find a way to prevent the oxidation of n-3 PUFA consumed in the diet, and one possible solution is vitamin E. Currently, this is the focus of Samuel Canner, a talented undergraduate student working with Steve Wassall in the Department of Physics at IUPUI. Canner explains that currently, whether vitamin E preferentially protects n-3 PUFA is not properly understood. He and colleagues at IUPUI and other institutions have been hard at work trying to figure out how vitamin E interacts with phospholipids into which n-3 PUFA incorporate in cell membranes and protects this influential group of molecules from being oxidized.

To do this, Canner runs sophisticated simulations on patches of model membranes in Nanoscale Molecular Dynamics (NAMD). These simulations allow the team to better understand the molecular interactions between vitamin E and n-3 PUFA. The simulations are run using Big Red II, a supercomputer at IU. Why Big Red II? Canner explains if they used normal computational machines, such complicated simulations would take months to complete. Specifically, he said, “Big Red II allows the simulations to be completed in a significantly more reasonable amount of time.” Because these simulations require a large computational capacity, it would take several months using a personal computer. Therefore, Big Red II helps the researchers run the simulations in a reasonable amount of time.

Currently, Canner is running more simulations and has begun experiments in the Wassall lab with support from the Undergraduate Research Opportunities Program (UROP) at IUPUI. Hopefully, the results will reveal conclusive evidence regarding the roles of vitamin E. Canner is hoping that this research would help science find a way to prevent the oxidation of n-3 PUFA incorporated into membranes, and so protect the health benefits contained in fish oils.

 


See the original article at IT News at IU

  • Dean's Welcome
  • Dean's Advisory Council
  • Facts & Statistics
  • Science Stories
  • News
  • Events
  • IU Indianapolis
  • Community Outreach
  • Employment Opportunities
  • Contact

School of Science resources and social media channels

  • Log in
  • Twitter
  • Facebook
  • Instagram
  • YouTube
  • LinkedIn