Martin Bard, Ph.D.
Emeritus Professor
Research
The research in my lab involves sterol biosynthesis and sterol uptake in three species of yeast-S. cerevisiae, C. albicans, and C. glabrata. In particular we are interested in protein-protein interactions among the fourteen enzymes that make up the sterol biosynthetic pathway. Additionally we are studying mechanisms by which yeasts take up sterol from the environment. This is important since many antifungal agents target the sterol biosynthetic pathway.
Education
- B.S. City College of New York, 1965
- Ph.D. University of California (Berkeley), 1971
Publications & Professional Activity
Valachovic, M., Bareither, B. M., Bhuiyan, M. S. A., Eckstein, J. Barbuch, R., Balderes, D., Wilcox, L., Sturley, S. L., Dickson, R. C. and Bard, M. Cumulative Mutations Affecting Sterol Biosynthesis In The Yeast Saccharomyces cerevisiae Result In Synthetic Lethality That Is Suppressed By Alterations In Sphingolipid Profiles. Genetics 173: 1893-1908, 2006
Loertscher, J., Larson, L.L, Matson, C.K., Parrish, M.L., Felthauser, A., Sturm, A., Tachibana, T., Bard, M. and Wright, R. Endoplasmic Reticulum Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae, Euk. Cell5:712-722, 2006
Rahier A, Darnet S, Bouvier F, Camara B, and Bard M. Molecular and enzymatic characterizations of novel bifunctional 3beta -hydroxysteroid-dehydrogenases/C4-decarboxylases from Arabidopsis thaliana. J. Biol. Chem. 281: 27264-27277, 2006
Bhuiyan, M.S.A., Eckstein, J., Barbuch, R., and Bard, M. Synthetic Lethal Interactions Involving Loss of the Yeast ERG24-the Sterol C-14 Reductase Gene. Lipids 42:69-76, 2007.Hughes, A.L., David W. Powell, D.W., Bard, M., Eckstein, J., Barbuch, R., Link, A.J., and Espenshade, P.J. Dap1/PGRMC1 Binds and Regulates Cytochrome P450 Enzymes. Cell Metab. 5:143-149, 2007
Nakayama, H., Tanabe, K., Bard, M., Hodgson, W., Wu, S., Takemori, D., Aoyama, T., Kumaraswami, N., Metzler, L., Takano, Y., Chibana, H., and Niimi, M. The Candida glabrata Putative Sterol Transporter Gene CgAUS1 Protects Cells Against Azoles in The Presence Of Serum. J. Antimicrobiol. Chemother. 60:1264-1272, 2007
Teske, B., Taramino, S., Bhuiyan, M.S.A., Kumaraswami, N. S., Randall, S.K., Barbuch, R., Eckstein, J., Balliano, G., and Bard, M. Genetic Analyses Involving Interactions Between the Ergosterol Biosynthetic Enzymes, Lanosterol Synthase (Erg7p) and 3-Ketoreductase (Erg27p) in the Yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta. 1781:359-366, 2008.
Williger, S.D., Puttikamonkul, S., Kim, K.-H., Burrtitt, J.B., Grahl, N., Metzler, L.J., Barbuch, R., Bard, M. Lawrence, C.B. and Cramer, R.A. A Sterol Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia, Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus. PLoS Pathog 4(11) 1-18 e1000200, 2008
Taramino, S., Valachovic, M., Oliaro-Bosso, S., Viola, F., Teske, B., Bard, M., and Balliano, G. Interactions Interactions of oxidosqualene cyclase (Erg7p) with 3-ketoreductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. Biochim. Biophys. Acta. 1801:156-162, 2010
Awards
- IUPUI School of Science Research Award, 2004
- Mycology Scholar Award, Burroughs Wellcome Fund, 1999
- Teaching Enhancement Recognition Award, IUPUI 1999
- Johnson and Johnson focused Giving Award Presenter, 1998